发明名称 |
ANTI-IL-33 ANTIBODIES AND USES THEREOF |
摘要 |
The present invention provides antibodies that bind to interleukin-33 (IL-33) and methods of using the same. The invention includes antibodies that inhibit or attenuate IL-33-mediated signaling. The antibodies of the invention may function to block the interaction between IL-33 and ST2. Alternatively, certain antibodies of the invention inhibit or attenuate IL-33-mediated signaling without blocking the IL-33/ST2 interaction. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human IL-33 with high affinity. The antibodies of the invention are useful for the treatment of diseases and disorders associated with IL-33 signaling and/or IL-33 cellular expression, such as inflammatory diseases, or allergic diseases. |
申请公布号 |
US2014271658(A1) |
申请公布日期 |
2014.09.18 |
申请号 |
US201414205512 |
申请日期 |
2014.03.12 |
申请人 |
Regeneron Pharmaceuticals, Inc. |
发明人 |
Murphy Andrew J.;Papadopoulos Nicholas J.;Orengo Jamie M. |
分类号 |
C07K16/24;A61K31/137;A61K45/06;A61K39/395 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
1. An isolated human monoclonal antibody or antigen-binding fragment thereof that binds human interleukin 33 (IL-33), wherein the antibody or antigen-binding fragment thereof inhibits or attenuates IL-33-mediated signaling. |
地址 |
Tarrytown NY US |