DEVICE AND METHOD FOR THE DETECTION AND DIAGNOSIS OF AGGRESSIVE AND METASTATIC CANCER AND CANCER STEM CELLS EMPLOYING PODOCALYXIN AND TRA BIOMARKERS

摘要

The invention relates to devices and methods to detect podocalyxin and TRA molecules in a biological sample obtained from a patient and therefore, to detect the presence of podocalyxin-expressing and TRA-expressing cancer stem cells in a patient. The invention further relates to devices and methods to determine a diagnosis of aggressive or metastatic cancer by employing podocalyxin and TRA as biomarkers.

主权项

1. A method of detecting the presence of podocalyxin and/or TRA molecules in a first patient, comprising:
obtaining a first biological sample from the first patient, the first sample selected from the group consisting of a blood-derived specimen, a seminal fluid specimen, a urine specimen, and combinations thereof; testing the first biological sample for the presence of podocalyxin and/or TRA molecules; and determining the presence or absence of podocalyxin and/or TRA molecules in the first biological sample.