| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing a nucleic acid derivative with an oxygen atom on a ribose ring being substituted by a -S-S- group; and a nucleic acid derivative produced by the method.SOLUTION: The production method of the nucleic acid derivative according to the present invention is a method for producing a nucleic acid derivative having a dithiane ring, where a carboxylate compound is obtained from a thiolsulfinate compound by Pummerer rearrangement reaction before a nucleic acid base group is introduced by Vorbruggen reaction. |
