METHOD AND SYSTEM FOR DOSE DETERMINATION OF RADIATION THERAPY

摘要

Methods for performing dose determination and cost function gradients in a radiation therapy are disclosed, which include: discretizing a volume-of-interest (VOI) into a set of voxels; identifying a set of beamlets which deposit dose contributions of radiation to the VOI, and each beamlet has a weight factor; transforming the dose contributions into a first domain, and transforming the weight factors into a second domain orthogonal to the first domain; calculate the local derivatives of a cost function of dose and cost function gradients with respect to the weights of the beamlets.

主权项

1. A method for performing dose determination, comprising:
creating a set of volume elements from a volume of interest in a physical object or system or a virtual model thereof; identifying a plurality of beamlets, each of said beamlets depositing a dose contribution of radiation to at least one subset of said volume elements; transforming the dose contributions of all beamlets for each of said volume elements into a first domain, yielding a set of transformed dose contributions for each of said volume elements; assigning a weight to each of said beamlets to create a set of weights; transforming the set of weights into a second domain orthogonal to the first domain, yielding a set of transformed weights; and determining a dose for each of said volume elements through summing up the elementwise products of the set of transformed dose contributions and the set of transformed weights.