Compositions and Devices of Poly-4-Hydroxybutyrate

摘要

Compositions of P4HB with high purity have been developed. The compositions are prepared by washing P4HB biomass prior to solvent extraction, and precipitating P4HB from solution. The same solvent is preferably used to wash the P4HB biomass, and as a non-solvent to precipitate the polymer from a P4HB solvent solution. The highly pure P4HB compositions are suitable for preparing implants. The implants may be used for the repair of soft and hard tissues.

主权项

1. A composition comprising poly-4-hydroxybutyrate polymer, the composition having at least one property selected from the group consisting of: (i) a nitrogen content of 40 ppm or less; (ii) a carbon content of 55.81%±0.5%; (iii) a hydrogen content of 7.02%±0.3% as determined by elemental combustion analysis, and (iv) a lipid content of less than 100 ppm.