GENERATION OF pH/TEMPERATURE/IONIC GRADIENTS ON A LATERAL FLOW PLATFORM FOR MODULATING PROTEIN INTERACTIONS

摘要

Lateral flow assay devices for determining the concentration of a biomolecular analyte in a sample and methods for measuring analyte concentration in sample using such lateral flow assay devices.

主权项

1. A lateral flow assay device comprising a multisite array of test sites for measuring a biomolecule analyte having a solid support including absorbent material for providing capillary flow comprising:
a) a sample portion for receiving a sample; b) a diagnostic portion comprising a multisite array of test sites each comprising a probe for the biomolecular analyte, wherein at each test site of the multisite array the conditions for the interaction between the biomolecular analyte and the probe can be varied independently; c) an absorbent portion of absorbent material for providing capillary flow; and d) at least one electrode,wherein the sample portion, diagnostic portion, and absorbent portion are in capillary flow communication resulting in a capillary flow from sample portion a) towards absorbent portion c), whereby the sample flows across the probe at each test site in the diagnostic portion to provide contact between the sample and such probe.