EXTENDED RELEASE COMPOSITIONS COMPRISING HYDROCODONE AND ACETAMINOPHEN FOR RAPID ONSET AND PROLONGED ANALGESIA THAT MAY BE ADMINISTERED WITHOUT REGARD TO FOOD

摘要

The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.