| 发明名称 |
ARTIFICIAL NUCLEIC ACIDS |
| 摘要 |
Artificial nucleosides including 2-methyl-nucleobase-substituted butane-1,3-diol nucleosides are disclosed. Four different stereoisomers of such nucleosides are possible. Oligonucleotides made up of the artificial nucleosides form homoduplexes of greater stability than DNA duplexes and have a reduced ability to hybridize to DNA or RNA. |
| 申请公布号 |
US2014275508(A1) |
申请公布日期 |
2014.09.18 |
| 申请号 |
US201414208530 |
申请日期 |
2014.03.13 |
| 申请人 |
Elitech Holding B.V. |
发明人 |
Scarr Noah;Lukhtanov Eugeny A. |
| 分类号 |
C07D473/18;C07F9/6561;C07D239/54;C07D473/34;C07D239/47 |
主分类号 |
C07D473/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. Nucleoside analogues of Formulas I and II: wherein B is a natural or artificial nucleic acid base; X is —CH2— or substituted carbon; and n is 1 or 2. |
| 地址 |
Spankeren NL |
