ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS

摘要

The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.

主权项

1. A compound with structure of Formula (I):or stereoisomer, salt, hydrate, solvate, or crystalline form thereof,
wherein
BNuc is a naturally occurring purine or pyrimidine base, or analog thereof;L is a lipophilic promoiety, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, or O-substituted glyceryl having the formula —CH2CH(OR1)—CH2(OR2) (II), wherein R1 and R2 are independently substituted or unsubstituted alkyl, or substituted or unsubstituted aryl;R is substituted or unsubstituted lower alkyl, substituted or unsubstituted lower heteroalkyl, substituted or unsubstituted lower cycloalkyl, substituted or unsubstituted lower heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted lower heteroaryl; andX is hydrogen, substituted or unsubstituted lower alkyl, or substituted or unsubstituted lower heteroalkyl.