REPRESSIBLE LETHAL SYSTEM FOR REGULATING INSECT POPULATIONS

摘要

Disclosed herein are components, systems and methods for regulating population of multicellular organisms, for example insects.

主权项

1. A recombinant insect, comprising a lethal genetic element that comprises:
a first polynucleotide encoding one or more toxins, wherein the first polynucleotide is operably linked with a first promoter; and a binding sequence for a repressible transactivator protein, wherein the binding sequence is operably linked with the first promoter and expression of the one or more toxins is activatable by the repressible transactivator protein; wherein the binding of the repressible transactivator protein to the binding sequence is repressible by vanillic acid, analogs or derivatives thereof.