TREATMENTS OF EXTRACELLULAR MATRICES OF THE EYE

摘要

System and methods for a corrective eye procedure include at least one application device configured to be positioned at a selected area of an eye (e.g., equatorial sclera, posterior sclera, cornea, etc.). The at least one device includes at least one channel and at least one illumination guide. A cross-linking agent source is coupled to the at least one channel. An illumination source is coupled to the at least one illumination guide. The at least one device delivers the cross-linking agent to the selected area of the eye. The at least one device delivers photo-activating light from the illumination source to the selected area of the eye after the cross-linking agent has been delivered. The photo-activating light includes one or more doses necessary for activating the cross-linking agent and for activating TGF-β isoforms to improve health of extracellular matrices in the selected area of the eye.

主权项

1. A system for conducting a corrective scleral procedure for an eye, comprising:
at least one insert configured to be positioned at a selected area of scleral tissue, the at least one insert including at least one channel and at least one illumination guide; a cross-linking agent source coupled to the at least one channel; and an illumination source coupled to the at least one illumination guide, wherein the at least one insert delivers the cross-linking agent to the selected area of scleral tissue via the at least one channel, and the at least one insert delivers photo-activating light from the illumination source to the selected area of scleral tissue after the cross-linking agent has been delivered, the photo-activating light including one or more doses necessary for generating cross-linking activity in the scleral tissue by activating the cross-linking agent and for activating TGF-β isoforms to improve health of extracellular matrices in the selected area of scleral tissue.