| 摘要 |
Disclosed are novel 1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs thereof, represented by the Formula I, wherein Ar, A, B, R3-R6 are defined herein. Compounds having Formula I are PARP inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of PARP activity, such as cancer.; |
| 主权项 |
1. A compound having the Formula I: or a pharmaceutically acceptable salt or prodrug thereof, wherein: Ar is an aryl or heteroaryl, substituted with a substituted carbonyl or methyl at the meta-position; A is (CHR2)n, O, S or NR7; n=0-3; B is (CHR1) O, S or NR7; m=0-3; R1-R6 independently are hydrogen, halo, optionally substituted amino, optionally substituted alkoxy, optionally substituted C1-10 alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, ethylenedioxo, nitro, cyano, acylamido, hydroxy, thiol, acyloxy, azido, carboxy, carbonylamido or optionally substituted alkylthiol; R7 is hydrogen, optionally substituted C1-10 alkyl, haloalkyl, alkenyl or alkynyl. |
