发明名称 |
CRYSTAL OF 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE 3/4 HYDRATE, METHOD FOR PRODUCING THE SAME AND CRYSTAL OF 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE HYDRATE |
摘要 |
Provided is a method for producing 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate, including:
reacting 2-aminomalonamide with a compound represented by the following formula [1] in the presence of a carboxylic acid to obtain 5-hydroxy-1H-imidazole-4-carboxamide:;wherein, in formula [1], each R independently represents a C1-3 alkyl group;reacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide with an acidic compound to obtain a 5-hydroxy-1H-imidazole-4-carboxamide acid salt or a hydrate thereof; andreacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide acid salt or hydrate thereof with a salt in the presence of an acidic solvent to obtain the 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate. |
申请公布号 |
US2014275568(A1) |
申请公布日期 |
2014.09.18 |
申请号 |
US201414226364 |
申请日期 |
2014.03.26 |
申请人 |
FUJIFILM Corporation |
发明人 |
FUJIMOTO Taisuke;HASHIMOTO Tomohiro;HAYASHI Katsuyuki;TANAKA Tomoyuki |
分类号 |
C07D233/90 |
主分类号 |
C07D233/90 |
代理机构 |
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代理人 |
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主权项 |
1. A method for producing 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate, comprising:
reacting 2-aminomalonamide with a compound represented by the following formula [1] in the presence of a carboxylic acid to obtain 5-hydroxy-1H-imidazole-4-carboxamide: wherein, in formula [1], each R independently represents a C1-3 alkyl group; reacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide with an acidic compound to obtain a 5-hydroxy-1H-imidazole-4-carboxamide acid salt or a hydrate thereof; and reacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide acid salt or hydrate thereof with a salt in the presence of an acidic solvent to obtain the 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate. |
地址 |
Tokyo JP |