OXABICYCLO [2.2.2] ACID GPR120 MODULATORS

摘要

The present invention provides compounds of Formula (I):;;or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.

主权项

1. A compound of Formula (I):or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:
X is independently CH2O or OCH2; L1 is independently a hydrocarbon linker substituted with 0-2 Rc, a hydrocarbon-heteroatom linker substituted with 0-2 Rc, or —(CH2)1-3—(C3-4 cycloalkyl substituted with 0-2 Rc)—(CH2)0-2—; wherein said hydrocarbon linker has one to six carbon atoms and may be straight or branched, saturated or unsaturated; and said hydrocarbon-heteroatom linker has one to four carbon atoms and one group selected from O, CO, S(O)p, NH, N(C1-4 alkyl), CONH, NHCO and NHCO2; R1 is independently selected from: C6-10 carbocycle and a 5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NRb, O, and S(O)p; wherein said carbocycle and heterocycle are substituted with 0-4 R3 and 0-1 R4; R2 independently selected from: OH, CO2H, —CONHSO2Re, and —CONH—(CH2)0-3-(5-membered heteroaryl comprising: carbon atoms and 1-4 heteroatoms selected from N, NRb, O, and S(O)p;); R3, at each occurrence, is independently selected from: halogen, C1-6 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 haloalkylthio, and NO2; R4 is independently -L2-R5; L2 is independently selected from: a bond, O, S, CH2, C(═O), and —OSO2; R5 is independently selected from: C1-6 alkyl, C2-6 alkenyl, C1-6 haloalkyl, —(CH2)n—C3-6 carbocycle and a 5- to 6-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NRb, O, and S(O)p; wherein each ring moiety is substituted with 0-2 Ra; Ra, at each occurrence, is independently selected from: halogen, C1-4 alkyl, C1-4 alkoxy, and C1-4 haloalkyl; Rb, at each occurrence, is independently selected from: H, C1-4 alkyl, and —(CH2)0-2-(phenyl substituted with 0-3 Rd); Rc, at each occurrence, is independently selected from: halogen, OH, C1-4 alkyl, C1-4 haloalkyl, and C1-4 alkoxy; Rd, at each occurrence, is independently selected from: halogen, C1-4 alkyl, C1-4 alkoxy, and C1-4 haloalkyl; Re is independently selected from: C1-4 alkyl and phenyl; p is, independently at each occurrence, selected from 0, 1, and 2; and n is, independently at each occurrence, selected from 0, 1, and 2.