发明名称 |
MORPHINE SULFATE METHANOLIC SOLVATE, PROCESSES FOR MAKING SAME AND RELATED COMPOSITIONS AND METHODS FOR TREATING PAIN |
摘要 |
Processes for reducing the amount of impurities, especially α,β-unsaturated ketones (ABUK), in materials containing morphine. Novel compounds, namely low ABUK morphine sulfate methanolic solvate, and a novel crystal form are also described. The method for making morphine sulfate methanolic solvate comprises mixing a morphine free base composition with methanol to form a solution and adding a liquid comprising sulfuric acid to the solution to form a morphine sulfate methanolic solvate precipitate. A method of making a morphine sulfate compound comprises drying the morphine sulfate methanolic solvate in the presence of water vapor, such that methanol molecules are removed and replaced with water vapor molecules. A composition for treating pain comprises the morphine sulfate compound and at least one pharmaceutically acceptable excipient. A method for treating pain comprises administering to a patient in need thereof the composition comprising the morphine sulfate compound and at least one pharmaceutically acceptable excipient. |
申请公布号 |
US2014275146(A1) |
申请公布日期 |
2014.09.18 |
申请号 |
US201414212390 |
申请日期 |
2014.03.14 |
申请人 |
Johnson Matthey Public Limited Company |
发明人 |
Marmor Robert S. |
分类号 |
C07D489/02 |
主分类号 |
C07D489/02 |
代理机构 |
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代理人 |
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主权项 |
1. A method of making a morphine sulfate methanolic solvate composition comprising:
mixing a morphine free base composition with methanol to form a solution; and adding a liquid comprising sulfuric acid to the solution to form a morphine sulfate methanolic solvate precipitate. |
地址 |
London GB |