| 发明名称 |
BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PRIMARY SCLEROSING CHOLANGITIS AND INFLAMMATORY BOWEL DISEASE |
| 摘要 |
Provided herein are methods of treating or ameliorating primary sclerosing cholangitis and inflammatory bowel disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating primary sclerosing cholangitis comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof. |
| 申请公布号 |
US2014275090(A1) |
申请公布日期 |
2014.09.18 |
| 申请号 |
US201414212428 |
申请日期 |
2014.03.14 |
| 申请人 |
Lumena Pharmaceuticals, Inc. |
发明人 |
GEDULIN Bronislava;GREY Michael;O'DONNELL Niall;KELLER Bradley T. |
| 分类号 |
C07D487/08;C07D249/14;C07C279/12;C07D295/15;C07D207/09 |
主分类号 |
C07D487/08 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating or ameliorating primary sclerosing cholangitis and inflammatory bowel disease (PSC-IBD) in an individual comprising non-systemically administering to the individual a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt or solvate thereof. |
| 地址 |
San Diego CA US |
