METHOD FOR PREPARING AMBRISENTAN

摘要

The present invention relates to the field of chemical synthesis, and discloses a preparation method of ambrisentan. In the preparation method, using (S)-phenethylamine as a resolving agent, to form two diastereomers with 2-[(4,6-dimethyl pyrimidine-2-yl)oxy]-3-methoxy-3,3-diphenyl propionic acid in a specific solvent; re-crystallising the same to obtain diastereomers with a lower solubility; followed by acid ionization to obtain ambrisentan. The method of the present invention has a yield of about 30%, uses a cheap resolving agent which is easy to obtain and recover, and is suitable for industrialized production.