THIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS

摘要

Provided herein are compounds of the formula (I):;;as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.

主权项

1. The compound according to formula (I): wherein: R1 is pyridinyl or phenyl; R2 is pyridinyl, unsubstituted phenyl or phenyl substituted with alkoxy; R3 is —OR4 or —NR5R6; R4 is hydrogen or lower alkyl; and one of R5 or R6 is hydrogen or methyl and the other is unsubstituted lower alkyl, unsubstituted phenyl, lower alkyl substituted with alkoxy or phenyl substituted with halogen, alkoxy or —NH-phenyl; or a pharmaceutically acceptable salt thereof.