TREATMENT OF OVARIAN CANCER WITH 2-AMINO-4H-NAPHTHO[1,2-b]PYRAN-3-CARBONITRILES

摘要

Methods for inhibiting the growth of ovarian cancer cells or other serosal cancer cells are disclosed. The method involves exposing the cells to a 2-amino-4H-naphtho[1,2-b]pyran-3-carbonitrile of formula:;;whereinY is CR1 or N and Z is CR5 or N.

主权项

1. A method of treating serosal cancer comprising administering to a patient diagnosed with serosal cancer a compound of formula:wherein:
Y is CR3 or N; Z is CR5 or N; R1 is chosen from H and (C1-C8)hydrocarbon; R2 is chosen from H, halogen, —CF3, —NO2, —CN, —NHC(═O)(C1-C8)hydrocarbon and —NHS2(C1-C8)hydrocarbon; R3 is chosen from H and halogen; R4 is chosen from H, halogen, —NO2, —CN, (C1-C8)hydrocarbon and —O—(C1-C8)hydrocarbon; and R5 is chosen from H, halogen, —NO2, —CN, —CH3, —NHC(═O )(C1-C8)hydrocarbon and —NHSO2(C1-C8)hydrocarbon.