PHTHALAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS

摘要

The invention relates to a compound of Formula I and methods of treating CFTR (cystic fibrosis transmembrane conductance regulator) mediated diseases, in particular cystic fibrosis, comprising the step of administering a therapeutically effective amount of a compound of Formula I to a patient in need thereof:;

主权项

1. A compound of Formula I: or a pharmaceutically acceptable salt, ester or prodrug thereof; wherein represents a single or double bond; R1 is selected from hydrogen, hydroxy, amino, —C1-C8 alkoxy, —C1-C8 cycloalkoxy, —C1-C8 alkylamino, and —C1-C8 dialkylamino; R2 is selected from hydrogen, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, CF3, —C1-C8 alkoxy, —C1-C8 alkylamino, and —C1-C8 dialkylamino; R3 is selected from hydrogen, C1-C8 alkyl, C2-C8 alkenyl, and C2-C8 alkynyl; R4 is selected from absent, hydrogen, halogen, hydroxyl, amino, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, CF3, NO2, CN, —C1-C8 alkoxy, —C1-C8 alkylamino, and —C1-C8 dialkylamino; R5 is selected from C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl and C3-C6 cycloalkyl; R6 is selected from halogen, hydroxyl, amino, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, —CF3, —NO2, —CN, —C1-C8 alkoxy, —C1-C8 alkylamino, and —C1-C8 dialkylamino; and, R7 is selected from hydrogen, halogen, hydroxyl, amino, C1-C8 alkyl, C2-C8 alkenyl, C2-C5 alkynyl, CF3, NO2, CN, —C1-C8 alkoxy, —C1-C8 alkylamino, and —C1-C8 dialkylamino.