IMAGING SYSTEM AND METHOD FOR FLUORESCENCE GUIDED SURGERY

摘要

Imaging systems for fluorescence guided surgery are provided. An imaging system comprises a light source unit for providing one or more illumination and excitation lights to a target, a detection unit for detecting reflectance and fluorescence from the target, an optical train for directing the one or more illumination and excitation lights from the light source unit to the target and for directing the reflectance and fluorescence from the target to the detection unit, and a control unit for controlling the light source unit and the detection unit. Imaging methods for fluorescence guided surgery are also provided.

主权项

1. An imaging system for rapid alternation of white-light reflectance image and one or more fluorescent images for fluorescence guided surgery applications, comprising:
(A) a light source unit for providing one or more illumination and excitation lights to a target, the light source unit comprising a plurality of light engines, wherein
(i) a first light engine in the plurality of light engines emits a first light for illuminating the target, and(ii) a second light engine in the plurality of light engines emits a second light for exciting a first fluorophore in the target; (B) a detection unit comprising a plurality of detectors for detecting reflectance and fluorescence from the target, thereby producing a plurality of images, wherein
(i) a first detector in the plurality of detectors detects the reflectance from the target, thereby producing a reflectance image in the plurality of images, and(ii) a second detector in the plurality of detectors detects a first fluorescence emitted by the excited first fluorophore, thereby producing a first fluorescence image; (C) an optical train for directing the one or more illumination and excitation lights from the light source unit to the target and for directing the reflectance and fluorescence from the target to the detection unit; and (D) a control unit for controlling the light source unit and the detection unit.