METHODS AND SYSTEMS FOR THE FILTERLESS REDUCTION OF LEUKOCYTES IN A BIOLOGICAL FLUID

摘要

Methods and systems for removing leukocytes from a biological fluid are disclosed. The methods and systems include a device that has a magnetic substrate coated with one or more polymeric materials that have an adhesion or adsorption affinity for leukocytes.

主权项

1. A method for removing leukocytes from a biological fluid comprising:
a) introducing a quantity of a biological fluid including leukocytes and other components into a biocompatible chamber; b) contacting said biological fluid with one or more removal devices comprising a magnetic substrate at least partially coated with one more polymeric materials inside said chamber; c) agitating said biological fluid with said at least one or more devices; d) applying a magnetic field external to said chamber in the vicinity of said biological fluid; e) gathering said one or more magnetic devices in a part of said chamber; and f) removing said other components from said chamber.