| 摘要 |
PROBLEM TO BE SOLVED: To provide microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof.SOLUTION: The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surfaces of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent are also provided. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. |
