METHODS, COMPOSITIONS, AND DEVICES FOR THE OCCLUSION OF CAVITIES AND PASSAGEWAYS

摘要

Provided herein are methods, compositions, and devices for occluding cavities or passageways in a patient, in particular cavities or passageways in the cardiovascular system of a patient, such as the LAA of a patient's heart. The methods, compositions, and devices can be used to percutaneously occlude the LAA, decreasing the risk of thromboembolic events associated with AF.

主权项

1. A method of occluding the left atrial appendage (LAA) of a patient comprising injecting a crosslinkable biomaterial into the LAA of the patient;
wherein the crosslinkable biomaterial crosslinks in situ in the LAA to form a biocompatible polymeric matrix; wherein the biocompatible polymeric matrix exhibits an equilibrium swelling ratio of less than about 8; and wherein the biocompatible polymeric matrix has a degradation rate effective to permit the LAA to be sealed via endothelialization prior to erosion of the biocompatible polymeric matrix.