发明名称 |
COMPOSITIONS AND METHODS FOR IMMUNE TOLERANCE INDUCTION TO FACTOR VIII REPLACEMENT THERAPIES IN SUBJECTS WITH HEMOPHILIA A |
摘要 |
Tolerance inducing peptide (TIP) derived from the amino acid reference locus (AARL) within a FVIII replacement product (FVIIIrp) based on the differences between the expression product of a subject's F8 gene (sFVIII) and the FVIIIrp to provide tolerance induction before, during, and/or after a FVIII replacement therapy in a subject suffering from Hemophila A is disclosed. Methods of deriving, making, and using the TIP are also disclosed. In some embodiments, the TIP is associated with a nanoparticle, e.g., PLGA or PLGA-PEMA nanoparticle. |
申请公布号 |
WO2014145524(A2) |
申请公布日期 |
2014.09.18 |
申请号 |
WO2014US30314 |
申请日期 |
2014.03.17 |
申请人 |
HAPLOMICS, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;DEPARTMENT OF VETERANS AFFAIRS |
发明人 |
HOWARD, TOMMY, E.;LA TERZA, VINCENT |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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