发明名称 |
USING TRUNCATED GUIDE RNAS (TRU-GRNAS) TO INCREASE SPECIFICITY FOR RNA-GUIDED GENOME EDITING |
摘要 |
CRISPR-Cas genome editing uses a guide RNA, which includes both a complementarity region, which binds the target DNA by base- pairing, and a Cas9-binding region, to direct a Cas9 nuclease to a target DNA. Further disclosed are methods for increasing specificity of RNA-guided genome editing using CRISPR/Cas9 systems by using truncated guide RNAs (tru-gRNAs). |
申请公布号 |
CA2906724(A1) |
申请公布日期 |
2014.09.18 |
申请号 |
CA20142906724 |
申请日期 |
2014.03.14 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
JOUNG, J. KEITH;SANDER, JEFFRY D.;FU, YANFANG;MAEDER, MORGAN |
分类号 |
C07D487/14;A61K31/519;A61K31/5377;A61K47/48;A61K51/04;C07H21/04;C12N15/00 |
主分类号 |
C07D487/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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