TISSUE PROTECTIVE PEPTIDE AND PEPTIDE ANALOG FOR PREVENTING AND TREATING DISEASE AND DISORDER ASSOCIATED WITH TISSUE DAMAGE

摘要

PROBLEM TO BE SOLVED: To provide isolated peptide and a peptide analog that have little or no potentially undesirable hematopoietic effect but have tissue protective activity in a responsive cell, tissue, or organ.SOLUTION: Isolated peptide or a peptide analog comprises a 9 to 29-residue amino acid sequence featuring a core structural motif selected from (1) two negatively charged amino acids and (2) one positively charged amino acid and one negatively charged amino acid. Core charged amino acids are flanked by 7 to 27 amino acids as described herein. In certain embodiments, the core charged amino acids are immediately adjacent to each other. In certain embodiments, the charged amino acids are separated by 1 to 5 amino acids or by a single polar amino acid.