PEPSINIZED COLLAGEN IMPLANTS AND BIOMEDICAL USES THEREOF

摘要

Disclosed are pepsinized collagen implants, such as membranes and sponges, and methods of making them, which entails solubilizing pepsinized collagen in a buffer containing a polyol, e.g., mannitol or sorbitol, wherein the buffer has a substantially neutral pH. Methods of using the pepsinized collagen implants for clinical applications are also disclosed.

主权项

1. A method of preparing a collagen implant for use in tissue repair, comprising:
(a) digesting collagen with pepsin, thus producing pepsinized collagen; (b) solubilizing the pepsinized collagen in a buffer composition comprising a polyol, wherein the buffer has a substantially neutral pH; (c) drying the thus-solubilized, pepsinized collagen; and optionally (d) reacting the collagen of (c) with a cross-linking agent, thus producing the collagen membrane.