发明名称 ORGANIC COMPOUNDS
摘要 Provided are PDE1 inhibitors of Formula I, processes for their production, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
申请公布号 US2014275131(A1) 申请公布日期 2014.09.18
申请号 US201414209258 申请日期 2014.03.13
申请人 LI Peng;ZHENG Hailin;ZHAO Jun;WENNOGLE Lawrence P. 发明人 LI Peng;ZHENG Hailin;ZHAO Jun;WENNOGLE Lawrence P.
分类号 C07D487/14;A61K31/5575;A61K45/06;A61K31/519 主分类号 C07D487/14
代理机构 代理人
主权项 1. A compound of Formula I: wherein (i) R1 is H or C1-4 alkyl (e.g., methyl or ethyl);(ii) R2 and R3 are independently H or C1-6 alkyl (e.g., methyl or ethyl);(iii) R4 is H or C1-4 alkyl (e.g., methyl or ethyl);(iv) R5 is aryl (e.g., phenyl) optionally substituted with one or more groups independently selected from —C(═O)—C1-6 alkyl (e.g., —C(═O)—CH3) and C1-6-hydroxyalkyl (e.g., 1-hydroxyethyl);(v) R6 and R7 are independently H or aryl (e.g., phenyl) optionally substituted with one or more groups independently selected from C1-6 alkyl (e.g., methyl or ethyl) and halogen (e.g., F or Cl), for example unsubstituted phenyl or phenyl substituted with one or more halogen (e.g., F) or phenyl substituted with one or more C1-6 alkyl and one or more halogen or phenyl substituted with one C1-6 alkyl and one halogen, for example 4-fluorophenyl or 3,4-difluorophenyl or 4-fluoro-3-methylphenyl; and(vi) n is 1, 2, 3, or 4, in free or salt form.
地址 New York NY US