SUBSTITUTED PYRAZOLE ANALOGS As RAR ANTAGONISTS

摘要

The present invention provides compounds of Formula I or a pharmaceutical salt thereof; methods of treating osteoarthritis and the pain associated with osteoarthritis using the compounds; and processes for preparing the compounds.;

主权项

1. A compound having a formula below:wherein:
A is CH or N; X is CH or N; R1 is selected from: —C(O)N(R3)2, and —C(O)R4; R2 is selected from: —C3-4 alkyl, —OCH(CH3)2, and —SCH(CH3)2; each R3 is independently selected from: H and —CH3; R4 is selected from: 4-morpholinyl, 1-piperidinyl, 4-thiomorpholinyl, —NH(CH2)3OH, and 4-methyl-1-piperazinyl; and provided that when one of A or X is N, the other one of A or X is CH; or a pharmaceutically acceptable salt thereof.