| 主权项 |
1. A compound of formula (I):or a pharmaceutically acceptable salt thereof, wherein:
Z1 is O, S, S(═O) or SO2; Z2 is N, S or CRa, where R2 is H, C1-4 alkyl or C1-4 haloalkyl; R1 is CN, halo, OH, C1-4 alkoxy, or C1-4 alkyl that is optionally substituted with one to three groups selected from halo, C1-4 alkoxy, CN, and hydroxyl; Ring B is selected from phenyl, pyridine, pyrimidine, pyrazine, pyridone, pyrimidone, pyrazinone, pyridazinone, and thiazole, each of which is optionally substituted with up to two groups selected from halo, OH, CN, C1-4 alkyl, C2-4 alkenyl, —O—(C1-4alkyl), NH2, NH—(C1-4alkyl), —N(C1-4 alkyl)2, —SO2R2, NHSO2R2, NHC(O)R2, NHCO2R2, C3-6 cycloalkyl, C5-6 heteroaryl, —O—C3-6 cycloalkyl, —O—C5-6 heteroaryl, C4-8 heterocycloalkyl, and —O—C4-8 heterocycloalkyl, where each C4-8 heterocycloalkyl and C5-6 heteroaryl contains up to three heteroatoms selected from N, O and S as ring members, and each C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, C5-6 heteroaryl, and C4-8 heterocycloalkyl is optionally substituted with up to three groups selected from oxo, hydroxyl, halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, and —(CH2)1-2Q where Q is OH, C1-4 alkoxy, —CN, NH2, —NHR3, —N(R3)2, —SO2R3, NHSO2R3, NHC(O)OR3, or NHC(O)R3;
each R2 and R3 is independently C1-4 alkyl; andRing B is optionally fused to a 5-6 membered aromatic or nonaromatic ring containing up to two heteroatoms selected from N, O and S, where the 5-6 membered ring can be substituted with halo, C1-4 alkyl, C1-4 haloalkyl, or C1-4 alkoxy; each Y is independently selected from C1-4 alkyl, C1-4 alkoxy, CN, halo, oxo, —(CH2)pOR4, —(CH2)pN(R4)2, —(CH2)pNHC(O)R4, —(CH2)pNHCOO(C1-4 alkyl), or two Y groups on Ring A are optionally taken together to form a ring fused to or bridging Ring A, where said fused or bridging ring optionally contains a heteroatom selected from N, O and S as a ring member, and is optionally substituted with up to two groups selected from C1-4 alkyl, C1-4 alkoxy, CN, halo, oxo, —(CH2)pOR4, —(CH2)p N(R4)2, —(CH2)pNHC(O)R4, and —(CH2)pNHCOO(C1-4 alkyl); each R4 is independently H or C1-4 alkyl; each p is independently 0, 1, or 2; q is 0, 1 or 2; Z3, Z4, and Z5 are independently selected from CH and N; L is —C(═O)—NH—[CY] or —NH—C(═O)—[CY], where [CY] indicates which atom of L is attached to CY; and CY is an aromatic ring selected from phenyl, pyridine, pyrimidine, pyrazine, pyridazine, pyridone, thiazole, isothiazole, oxazole, pyrazole, and isoxazole, wherein the ring is optionally fused to a thiophene, imidazole, oxazolone, or pyrrole ring; and CY is substituted with up to two groups selected from halo, CN, R5, ORS, SO2R5, OH, NH2, NHR5, and —N(R5)2,
wherein each R5 is independently C1-4 alkyl, C4-6 heterocyclyl, or C3-8 cycloalkyl, and R5 is optionally substituted with up to three groups selected from oxo, halo, CN, R6, OH, OR6, SO2R6, NH2, NHR6, N(R6)2, NHSO2R6, NHCOOR6, NHC(═O)R6, —CH2OR7, —CH2N(R7)2, wherein each R6 is independently C1-4 alkyl, and each R7 is independently H or C1-4 alkyl;and two R4, R5, R6, or R7 on the same nitrogen atom can be taken together to form a 5-6 membered heterocyclic ring optionally containing an additional N, O or S as a ring member and optionally substituted with up to two groups selected from C1-4 alkyl, oxo, halo, OH, and C1-4 alkoxy. |
