HYALURONIC ACID DERIVATIVES

摘要

The present disclosure relates to hyaluronic acid derivatives, and in particular, derivatives in which the N-acetyl group of hyaluronic acid has been substituted, and methods and uses thereof.

主权项

1. A hyaluronic acid derivative comprising repeating units of a disaccharide comprising glucuronic acid and N-acetylglucosamine, wherein a portion of the N-acetyl groups of the N-acetylglucosamine have been independently substituted with hydrogen or a group of the formula —N—C(O)—(C2-C20)-alkyl, —N—C(O)—(C2-C20)-alkenyl or —N—C(O)—(C2-C20)-alkynyl, and wherein the hyaluronic acid derivative has a molecular weight of at least about 20 kDa, or a pharmaceutically acceptable salt, ester, or glucoside thereof.