COORDINATION COMPLEXES, PHARMACEUTICAL SOLUTIONS COMPRISING COORDINATION COMPLEXES, AND METHODS OF TREATING PATIENTS

摘要

A coordination complex having a physiologically acceptable pKa includes a metal and a biologically active agent. The pKa of the coordination complex is less than the pKa of the biologically active agent. A pharmaceutical solution for treating a patient includes a coordination complex and water, wherein the coordination complex is at least partially soluble in the water at physiological pH and in a therapeutically efficacious concentration. A method for treating a patient includes administering a pharmaceutical solution including a coordination complex and water to a patient in need of a biologically active agent.

主权项

1. A metal coordination complex of a biologically active moiety and a metal, wherein the biologically active moiety is selected from the group consisting of: mycophenolate, fingolimod, baclofen, acamprosate, tixocortol, pregabalin, 7-phenyl-2,4,6-hepta-trienal hydroxamic acid, (S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid, eglumegad, (2S,2′R,3′R)-2-(2′,3′-dicarboxycyclo-propyl)glycine, remacemide, azathioprine, zonisamide, balsalazide, dobutamine, epinephrine, ganciclovir, 6-MP, modafinil, norepinephrine, ribavirin, zoledronic acid, and their derivatives.