| 发明名称 |
EPIGENETIC BIOMARKER ADAMTS9 FOR DIAGNOSIS AND PROGNOSIS OF GASTRIC CANCER |
| 摘要 |
The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the ADAMTS9 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing ADAMTS9 gene expression or activity. |
| 申请公布号 |
US2014274908(A1) |
申请公布日期 |
2014.09.18 |
| 申请号 |
US201313797300 |
申请日期 |
2013.03.12 |
| 申请人 |
The Chinese University of Hong Kong |
发明人 |
YU JUN;Sung Joseph Jao Yiu |
| 分类号 |
C07K14/435;C12Q1/68;G01N33/68 |
主分类号 |
C07K14/435 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for detecting gastric cancer in a subject, comprising the steps of:
(a) measuring expression level of ADAMTS9 in a sample taken from the subject, and (b) comparing the expression level obtained in step (a) with a standard control, wherein a decrease in the expression level of ADAMTS9 when compared with the standard control indicates the subject having gastric cancer. |
| 地址 |
Shatin CN |
