Methods And Non-Immunogenic Compositions For Treating Inflammatory Disorders

摘要

Methods for making non-immunogenic anti-inflammatory cytokine compositions, comprising (a) obtaining a liquid comprising cytokine producing cells from a mammalian donor; (b) contacting the liquid with a solid extraction material to generate a composition rich in interleukin-1 receptor antagonist; and performing one or both of (i) removing cells from the composition and (ii) freezing the composition. The compositions comprise two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII, Compositions may also contain white blood cells and platelets.

主权项

1. A method for making a non-immunogenic anti-inflammatory cytokine composition, comprising:
(a) obtaining a cytokine cell suspension from a mammalian donor; (b) contacting the suspension with solid extraction material to generate a composition rich in interleukin-1 receptor antagonist; and (c) performing one or both of:
(i) removing cells from the composition; and(ii) freeze drying the composition to produce the non-immunogenic anti-inflammatory cytokine composition.