METHOD OF GENERATING AN INDEX SCORE FOR MBL DEFICIENCY TO PREDICT CARDIODIABETES RISK

摘要

This application relates to methods of predicting susceptibility or likelihood of a clinically-relevant mannose-binding lectin (MBL)-deficient subject to develop a cardiovascular disease and/or cardiodiabetes. The methods include measuring MBL mass or concentration and, optionally, measuring MBL activity, at least one other biomarker and/or genotyping of MBL gene and its promoters; combining the information obtained into a calculated MBL-inclusive index score that involves mathematical transformation; and assigning a risk of cardiadiabetic status and clinical endpoints based on the determination and comparison of the MBL inclusive index to reference values from a population.

主权项

1. A method for predicting susceptibility or likelihood of a subject having a clinically-relevant mannose-binding lectin (MBL) deficiency to develop cardiodiabetes, comprising:
a) obtaining a measurement value of MBL mass and, optionally, a measurement value of MBL activity level; b) calculating an MBL-inclusive index score based one or both MBL measurements, wherein the index score calculation involves a mathematical transformation, and c) comparing the MBL-inclusive index to reference values from a population; wherein an elevated MBL-inclusive index score correlates with a range in a higher unit of an ordered distribution of the population and indicates that the subject is less susceptible to or has a less likelihood of developing cardiovascular disease and/or cardiodiabetes, and wherein a low MBL-inclusive index score correlates with a range in a lower unit of an ordered distribution of the population and indicates that the subject is more susceptible to or has an increased likelihood of developing cardiovascular disease and/or cardiodiabetes.