| 摘要 |
This invention relates generally to neuropeptide Y (“NPY”) Y4 receptor agonists including pancreatic polypeptide (PP), analogs thereof, and peptide fragments of PP, e.g. PP(32-36), and analogs thereof, to pharmaceutical compositions containing such Y4 receptor agonists, and to methods for treatment of mammals using the same. The NPY Y4 receptor agonists may be administered to mammals either alone or in combination with NPY Y2 receptor agonists including peptide YY (PYY) (3-36), analogs thereof, and to peptide fragments of PYY(3-36), e.g. PYY(22-36) and PYY(25-36), and analogs thereof, such as to control food intake in mammals, blood pressure, cardiovascular response, libido, circadian rhythm, hyperlipidimia, chronic pancreatitis, and nonalcoholic fatty liver disease including nonalcoholic steatohepatitis. |
| 主权项 |
1. A compound having the formula: wherein: each X, independently, is an aromatic amino acid; each Y, independently, is an amino acid having a guanidino group; each Z, independently, is an aliphatic amino acid; n=1, 2, 3 or 4; and wherein the compound optionally includes one or two pseudopeptide bonds where each pseudopeptide bond is independently selected from —CH2—NH—, —CH2—S—, —CH2—CH2—, —CH2—O— and CH2—CO—. |
