发明名称 |
ANTIGEN DERIVED FROM EXTRACELLULAR DOMAIN OF MULTI-TRANSMEMBRANE PROTEIN AND USES THEREOF |
摘要 |
A multi-transmembrane protein antigen includes a polypeptide corresponding to an extracellular loop of the multi-transmembrane protein, the N-terminal and C-terminal of the polypeptide being fixed on a solid substrate or the N-terminal and C-terminal being attached to both ends of a linker to form a cyclic structure, an antibody specifically binding to the antigen or an antigen-binding fragment thereof, and a method for screening an antibody specifically binding to the antigen. The present invention may be usefully employed for effective production of antibodies for multi-transmembrane proteins that play important roles in disease-related phenomena such as cell signaling. |
申请公布号 |
US2014274755(A1) |
申请公布日期 |
2014.09.18 |
申请号 |
US201313803090 |
申请日期 |
2013.03.14 |
申请人 |
REFERENCE BIOLABS INC. |
发明人 |
SHIN Young Kee;KIM Young-Deug;CHOI Jun Young;LEE Myung Seok |
分类号 |
C07K17/08;C07K16/18 |
主分类号 |
C07K17/08 |
代理机构 |
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代理人 |
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主权项 |
1. A multi-transmembrane protein antigen comprising a polypeptide corresponding to an extracellular loop of a multi-transmembrane protein, wherein an N-terminal and a C-terminal of the polypeptide are fixed on a solid substrate, or an N-terminal and a C-terminal of the polypeptide are attached to both ends of a linker to form a cyclic structure. |
地址 |
Seoul KR |