发明名称 |
MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF FIBROTIC DISEASES |
摘要 |
The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic conditions. The invention provides polypeptide and nucleic acid TARGETs, siRNA sequences based on these TARGETs and antibodies against the TARGETs. The invention is further related to pharmaceutical composition comprising siRNA sequences based on the TARGETs and antibodies against the TARGETs for use in the treatment of fibrotic conditions. The invention further provides in vitro methods for reduction or inhibition of macrophage differentiation into alternatively-activated macrophages (M2). |
申请公布号 |
WO2014139883(A1) |
申请公布日期 |
2014.09.18 |
申请号 |
WO2014EP54441 |
申请日期 |
2014.03.07 |
申请人 |
GALAPAGOS NV |
发明人 |
JANSSEN, RICHARD ANTONIUS JOZEF;LEKKERKERKER, ANNEMARIE NICOLETTE;VAN ES, THOMAS;STALLEN, JOHANNES MELCHIOR PETRUS |
分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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