MODIFIED MOLECULES RESISTANT TO PROTEOLYTIC DEGRADATION

摘要

An object of the present invention is to provide modified Fc-containing molecules that are resistant to proteolytic degradation compared to wild-type Fc-containing molecules to be used in the prevention or treatment of diseases associated with Pseudomonas aeruginosa. According to the present invention, there is provided modified Fc-containing molecules are resistant to proteolytic degradation by pseudolysin/LasB secreted by any strain of Pseudomonas aeruginosa.