| 摘要 |
<p>Herein is disclosed methods and devices for the treatment of microbial infection; for example skin, nail matrix and nail plate infections such as onychomycosis. The technique combines ultrasound stimulation, where an ultrasound transducer is applied over the skin or nail matrix, to increase porosity and a nonthermal plasma generator that produces antimicrobial gases effective in killing various infective microorganisms, which include fungus, bacteria, yeast, and mold. The plasma effluent gas applied to the nail has an increased permeability into the nail due to the ultrasound assisted porosity and pressure vibrations that assist the gas transport into the nail. The combination of ultrasound-assisted plasma gas therapy can be used to treat, cure and provide prophylaxis. The invention can achieve markedly better cure rates than present methods of either topical drug application or orally administrating the drugs without any adverse systemic side effects.</p> |
