SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF

摘要

The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.

主权项

1. A compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 and R3 are OR5 and R2 and R4 are H, or R2 and R4 are OR5 and R1 and R3 are H, or R2 and R3 are OR5 and R1 and R4 are H; each R5 is independently H or C1-6 acyl; and each R6 is independently selected from the group consisting of: H, C1-6 alkyl, C3-6 alkenyl, C3-6 alkynyl, and C1-6 alkoxy, wherein the C1-6 alkyl, C3-6 alkenyl, C3-6 alkynyl, or C1-6 alkoxy are optionally substituted from one up to the maximum number of substituents with one or more of fluoro, OH, or methyl, or the two R6 groups are connected together with the nitrogen atom to which they are attached to form a ring, said ring optionally independently substituted from one up to the maximum number of substituents with one or more of fluoro, OH, or methyl.