| 发明名称 |
METHODS AND COMPOSITIONS FOR TREATMENT OF BREAST CANCER |
| 摘要 |
Provided are methods of treating breast cancer in a subject in need thereof comprising administering to the subject an effective amount of an inhibitor of miR-105 or an inhibitor of miR-122 are provided. Also provided herein are methods of determining a level of miR-105 or a level of miR-122 in a subject that has or is at risk for developing breast cancer. The method includes obtaining a biological sample from the subject and determining a level of miR-105 or a level of miR-122 or a combination thereof in the biological sample, wherein a higher level of miR-105 or miR-122 as compared to a control indicates that the subject has or is at risk of developing breast cancer. |
| 申请公布号 |
US2014274769(A1) |
申请公布日期 |
2014.09.18 |
| 申请号 |
US201414203173 |
申请日期 |
2014.03.10 |
| 申请人 |
City of Hope |
发明人 |
Wang Shizhen Emily;WU Xiwei;Fong Miranda Y. |
| 分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of determining a level of miR-105 or a level of miR-122 or a combination thereof in a subject that has or is at risk for developing breast cancer, the method comprising the steps of:
(a) obtaining a biological sample from the subject; and (b) determining a level of miR-105 or a level of miR-122 or a combination thereof in the biological sample. |
| 地址 |
Duarte CA US |
