BIOMARKERS FOR DETECTING THE PRESENCE OF BACTERIA

摘要

In some aspects, provided are methods relating to the use of bacterial N-methyl-2 superfamily proteins as a biomarker for the presence of bacteria in a sample. The invention also relates to novel methods of diagnosis of the presence of bacteria in a liquid or solid sample, detection of bacterial infections in humans or animals, and use of antibodies or other specific binding molecules capable of binding to N-methyl-2 superfamily proteins.

主权项

1. A method of detecting the presence of bacteria in a sample comprising:
(a) contacting the sample with an antibody, fragment thereof, aptamer or ligand capable of binding a protein in the N-methyl-2 superfamily to form one or more complexes in the presence of the N-methyl-2 superfamily proteins, if any, in the sample; and (b) detecting the presence of the one or more said complexes,wherein the presence of at least one complex indicates the presence of bacteria.