| 摘要 |
Disclosed herein are compounds of formula (I) wherein L1, L2, L3, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described. |
| 申请人 |
CAYMAN CHEMICAL COMPANY, INC.;MYOMETRICS LLC |
发明人 |
BARRETT, STEPHEN, DOUGLAS;COLOMBO, JOSEPH, MICHAEL;GERMAIN, BRADLEE, DAVID;ENDRES, GREGORY, WILLIAM;KORNILOV, ANDRIY;KRAMER, JAMES, BERNARD;UZIEBLO, ADAM;CISKE, FRED, LAWRENCE;MAXEY, KIRK, M.;O'MALLEY, JAMES, PAUL;OWEN, THOMAS, ALLEN |
