CYSTEAMINE IN THE TREATMENT OF FIBROTIC DISEASE

摘要

Fibrotic diseases are characterized by the replacement of healthy tissue with scar tissue and extracellular matrix in response to tissue damage. Here we describe the reduction of extracellular matrix (ECM) deposition, interstitial fibroblasts, interstitial volume, expression of Collagen I mRNA and protein, expression of profibrotic cytokines and macrophage infiltration by Cysteamine treatment.

主权项

1. A method of treating a fibrotic disease comprising administering, to a patient in need thereof, an effective amount of cysteamine, or a salt thereof; wherein the administration of cysteamine, or a salt thereof, results in amelioration of a fibrotic disease in the patient.