| 发明名称 |
MicroRNA-BASED APPROACH TO TREATING MALIGNANT PLEURAL MESOTHELIOMA |
| 摘要 |
The invention relates to microRNA mimics, corresponding to the miR-15/107 family, and to methodology for using microRNA mimics to treat malignant pleural mesothelioma (MPM) by restoring regulation of the expression of target genes of the miR-15/107 family in MPM tumor cells. |
| 申请公布号 |
US2014275223(A1) |
申请公布日期 |
2014.09.18 |
| 申请号 |
US201313801010 |
申请日期 |
2013.03.13 |
| 申请人 |
Asbestos Diseases Research Institute |
发明人 |
Reid Glen;Zandwijk Nico van |
| 分类号 |
A61K31/713;A61K45/06 |
主分类号 |
A61K31/713 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A double-stranded microRNA mimic for the treatment of malignant pleural mesothelioma (MPM), wherein the microRNA mimic comprises:
(a) a mature sequence corresponding to a miR-15/107 family member; and (b) a passenger strand,wherein the mature sequence contains AGCAGC at positions 2-7 or 1-6 at the 5′ end. |
| 地址 |
Concord AU |
