| 主权项 |
1. A method of treatment of a disease or condition which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein X is selected from the group consisting of O and S; Y is selected from the group consisting of O and S; Z is selected from the group consisting of Z1, Z2, Z3, and Z4, wherein Z1 is Z2 is Z3 isand
Z4 isprovided that Z is only Z4 when at least one of X or Y is S;
R1 is selected from the group consisting of hydrogen, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)haloalkyl, unsubstituted aryl(C1-C4)alkyl, substituted aryl(C1-C6)alkyl, (C1-C6)heteroalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl; R2 is selected from the group consisting of hydrogen, halogen, cyano, and (C1-C6) alkoxy; R3 is selected from the group consisting of hydrogen, halogen, (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) alkoxy, cyano, and N,N-dimethylamino; R4 is selected from the group consisting of tetrazole, oxadiazolone, thiadiazolone, methylsulfonylcarbamoyl, and N-hydroxycarbamoyl; and R5 is selected from the group consisting of carboxy, tetrazole, oxadiazolone, thiadiazolone, methylsulfonylcarbamoyl, and N-hydroxycarbamoyl. |
