| 摘要 |
Compounds of the formula I:;;or pharmaceutically acceptable salts thereof,
wherein m, n, p, q, r, A, X1, X2, X3, X4, X5, X6, Y, Z, G, R1a, R2a, R1b, R2b, R3, R4, R5 and R6 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis. |
| 主权项 |
1. A compound of formula I:or a pharmaceutically acceptable salt thereof,wherein:
m is 0 or 1 n is 0 or 1 p is from 0 to 3; q is 1 or 2; r is from 1 to 3; A is: a bond; —CH2—; —C(O)—; —NRa—; —C(O)NRa—(CH2)t—; —(CH2)t—NRaC(O)—; —O—; —S—; or —SO2—; t is from 0 to 4; one of X1, X2, X3 and X4 is N and the others are CRb; or two of X1, X2, X3 and X4 are N and the others are CRb; or three of X1, X2, X3 and X4 are N and the other is CRb; or each of X1, X2, X3 and X4 is CRb; Y is: —O—; —S—; SO2—; —CRcRd—; or —NRe—; Z is: CH; or N; G is: —NRf—; or —O—; R1a, R2a, R1b and R2b each independently is: hydrogen; or C1-6alkyl which may be unsubstituted or substituted one or more times with halo; R3 is: hydrogen; C1-6alkyl; C3-6 cycloalkyl; C3-6cycloalkyl-C1-6alkyl; C1-6alkoxy-C1-6alkyl; or hydroxy-C1-6alkyl, wherein the C1-6alkyl and C3-6cycloalkyl moities may be substituted one or more times with halo; each R4 is independently: C1-6alkyl; halo; C1-6alkoxy; or cyano; wherein the C1-6alkyl moieties may be unsubstituted or substituted one or more times with halo; R5 is: hydrogen; halo; or C1-6alkyl which may be unsubstituted or substituted one or more times with halo; R6 is: hydrogen; halo; carboxy; C1-6alkyl-carbonyl; C1-6alkoxy-carbonyl; oxo; hydroxy; aminocarbonyl; N—C1-6alkyl-aminocarbonyl; N,N-di-C1-6alkyl-aminocarbonyl; or C1-6alkyl which may be unsubstituted or substituted one or more times with halo; or oxo; or R5 and R6 together with the atoms to which they are attached may form a four, five, six or seven membered ring; Ra is: hydrogen; or C1-6alkyl which may be unsubstituted or substituted one or more times with halo; each Rb is independently: hydrogen; C1-6alkyl; halo; C1-6alkoxy; or cyano; wherein the C1-6alkyl moieties may be unsubstituted or substituted one or more times with halo; Rc is: hydrogen; halo; or C1-6alkyl which may be unsubstituted or substituted one or more times with halo; Rd is: hydrogen; C1-6alkyl; C3-6cycloalkyl; C3-6cycloalkenyl; C3-6cycloalkyl-C1-6alkyl; halo; C1-6alkyl-carbonyl; C3-6 cycloalkyl-carbonyl; C3-6 cycloalkyl-C1-6alkyl-carbonyl; cyano —C1-6alkyl-carbonyl; hydroxy-C1-6alkyl-carbonyl; C1-6alkoxy-C1-6alkyl-carbonyl; carboxy; N-cyano-aminocarbonyl; N-cyano-N—C1-6alkyl-aminocarbonyl; N—C1-6alkyl-acetimidamidyl; N,N′-di-C1-6alkyl-acetimidamidyl; N′-cyano-N—C1-6alkyl-acetimidamidyl; N′-hydroxy-acetimidamidyl; N′—C1-6alkoxy-acetimidamidyl; N′-hydroxy-N—C1-6alkyl-acetimidamidyl; N′—C1-6alkoxy-N—C1-6alkyl-acetimidamidyl; 2-nitro-1-N—C1-6alkylamino-vinyl; formyl; C1-6alkyl-sulfonyl; C3-6 cycloalkyl-sulfonyl; C3-6 cycloalkyl-C1-6alkyl-sulfonyl; C1-6alkyl-sulfonyl-C1-6alkyl; aminocarbonyl; N-hydroxy-aminocarbonyl; N—C1-6alkoxy-aminocarbonyl; N—C1-6alkyl-aminocarbonyl; N-hydroxy-N—C1-6alkyl-aminocarbonyl; N—C1-6alkoxy-N—C1-6alkyl-aminocarbonyl; N,N-di-C1-6alkyl-aminocarbonyl; aminosulfonyl; N—C1-6alkyl-aminosulfonyl; N,N-di-C1-6alkyl-aminosulfonyl; cyano; C1-6alkoxy; C1-6alkyl-sulfonylamino; N—C1-6alkyl-sulfonylaminocarbonyl; N—(C1-6alkyl-sulfonyl)-N—C1-6alkyl-aminocarbonyl; N—(C1-6alkyl-sulfonyl)-amino-C1-6alkyl; amino; N—C1-6alkyl-amino; N,N-di-C1-6alkyl-amino; halo-C1-6alkyl; heterocyclyl; heteroaryl; or hydroxyl; wherein the C1-6alkyl moieties may be unsubstituted or substituted one or more times with halo; and wherein the heterocyclyl, heteroaryl, C3-6cycloalkyl, C3-6cycloalkenyl and C3-6cycloalkyl-C1-6alkyl moieties may be unsubstituted or substituted one or more times with Rg; or Rc and Rd together with the atoms to which they are attached may form a four, five, six or seven membered ring that may optionally include one or two heteroatoms selected from —O—, —NRa— or —S—, and which may be optionally substituted one or more times with Rg; Re is: hydrogen; C1-6alkyl; C3-6cycloalkyl; C3-6cycloalkenyl; C3-6cycloalkyl-C1-6alkyl; C1-6alkyl-carbonyl; C3-6cycloalkyl-carbonyl; C3-6cycloalkyl-C1-6alkyl-carbonyl; cyano-C1-6alkyl-carbonyl; hydroxy-C1-6alkyl-carbonyl; C1-6alkoxy-C1-6alkyl-carbonyl; N-cyano-aminocarbonyl; N-cyano-N—C1-6alkyl-aminocarbonyl; N—C1-6alkyl-acetimidamidyl; N,N′-di-C1-6alkyl-acetimidamidyl; N′-cyano-N—C1-6alkyl-acetimidamidyl; N′-hydroxy-acetimidamidyl; N′—C1-6alkoxy-acetimidamidyl; N′-hydroxy-N—C1-6alkyl-acetimidamidyl; N′—C1-6alkoxy-N—C1-6alkyl-acetimidamidyl; 2-nitro-1-N—C1-6alkylamino-vinyl; formyl; C1-6alkyl-sulfonyl; C3-6 cycloalkyl-sulfonyl; C3-6 cycloalkyl-C1-6alkyl-sulfonyl; C1-6alkyl-sulfonyl-C1-6alkyl; aminocarbonyl; N-hydroxy-aminocarbonyl; N—C1-6alkoxy-aminocarbonyl; N—C1-6alkyl-aminocarbonyl; N-hydroxy-N—C1-6alkyl-aminocarbonyl; N—C1-6alkoxy-N—C1-6alkyl-aminocarbonyl; N,N-di-C1-6alkyl-aminocarbonyl; aminosulfonyl; N—C1-6alkyl-aminosulfonyl; N,N-di-C1-6alkyl-aminosulfonyl; cyano; C1-6alkyl-sulfonylamino; C1-6alkyl-sulfonylamino-C1-6alkyl; N—(C1-6alkyl-sulfonyl)aminocarbonyl; N—(C1-6alkyl-sulfonyl)-N—C1-6alkyl-aminocarbonyl; N—(C1-6alkyl-sulfonyl)-amino-C1-6alkyl; halo-C1-6alkyl; heterocyclyl; or heteroaryl; wherein the C1-6alkyl moieties may be unsubstituted or substituted one or more times with halo; and wherein the heterocyclyl, heteroaryl, C3-6cycloalkyl, C3-6cycloalkenyl and C3-6cycloalkyl-C1-6alkyl moieties may be unsubstituted or substituted one or more times with Rg; or Re and one of R5 and R6 together with the atoms to which they are attached may form a four, five, six or seven membered ring that may optionally include one or two additional heteroatom selected from —O—, —NRa- or —S—, and which may be optionally substituted one or more times with Rg; or one of Rc and Rd and one of R5 and R6 together with the atoms to which they are attached may form a four, five, six or seven membered ring that may optionally include an additional heteroatom selected from —O—, —NRa— or —S—, and which may be optionally substituted one or more times with Rg; Rf is: hydrogen; C1-6alkyl; C3-6 cycloalkyl; C3-6cycloalkyl-C1-6alkyl; C1-6alkoxy-C1-6alkyl; or hydroxy-C1-6alkyl, wherein the C1-6alkyl and C3-6cycloalkyl moities may be substituted one or more times with halo; or Rf and R3 together with the atoms to which they are attached may form a five, six or seven membered ring that may be optionally substituted one or more times with Rh; Rg is: C1-6alkyl; halo; oxo; hydroxy; acetyl; or C1-6alkoxy; wherein the C1-6alkyl moieties may be unsubstituted or substituted one or more times with halo; and Rh is: C1-6alkyl; halo; oxo; hydroxy; acetyl; or C1-6alkoxy; wherein the C1-6alkyl moieties may be unsubstituted or substituted one or more times with halo; or two of Rh together with the atoms to which they are attached may form a four, five, six or seven membered ring that may optionally include an additional heteroatom selected from —O—, —NRa— or —S—, and which may be optionally substituted one or more times with Rg. |
