| 发明名称 |
CONJUGATE BASED SYSTEMS FOR CONTROLLED DRUG DELIVERY |
| 摘要 |
Conjugates which comprise a drug and a ligand which includes a first saccharide; wherein the conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic or pharmacodynamic property of the conjugate is sensitive to serum concentration of a second saccharide. Exemplary conjugates and sustained release formulations are provided in addition to methods of use and preparation. |
| 申请公布号 |
US2014274888(A1) |
申请公布日期 |
2014.09.18 |
| 申请号 |
US201414291021 |
申请日期 |
2014.05.30 |
| 申请人 |
SmartCells, Inc. |
发明人 |
Zion Todd C.;Lancaster Thomas M. |
| 分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A conjugate comprising a drug conjugated to one or more ligands wherein at least one ligand comprises a mannose, glucose, or L-fucose saccharide; wherein the conjugate is characterized in that, when the conjugate is administered to a mammal in the absence of an exogenous multivalent saccharide-binding molecule, at least one pharmacokinetic or pharmacodynamic property of the conjugate is sensitive to serum concentration of a saccharide. |
| 地址 |
Whitehouse Station NJ US |
